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Zoloft (sertraline) is a selective serotonin reuptake inhibitor specially designed for the treatment of conditions such as depression, panic disorder and a number of other ones. This medicine works by affecting chemicals in the brain that can get imbalanced. You are supposed to talk to your health care provider if you have recently taken any of the following medications: isocarboxazid, pimozide, selegiline, tranylcypromine, phenelzine, or rasagiline. You will need to wait for at least 14 days after taking pimozide or any of the MAO inhibitors listed, as otherwise a dangerous reaction is possible. Your health condition will need to be monitored during the first several weeks to make sure you get the progress you were hoping for and do not experience any serious side effects. Serious side effect that will need to be reported to your health care provider as soon as you get them may include: seizure, high fever, stiff muscles, nausea, memory problems, headache, shallow breathing, vomiting, trouble concentrating, loss of appetite, diarrhea, and confusion. Less serious side effects are a lot more likely. You do not need to report such side effects as dizziness, upset stomach, changes in appetite, constipation, mild nausea, dry mouth, drowsiness, and sleep problems to your health care provider as they are unlikely to get worse. However in some cases they do - and that's when a doctor needs to be contacted. The following symptoms may indicate this medicine is not working for you in the way it should: impulsiveness, suicidal thoughts, aggressiveness, irritability, restlessness, trouble sleeping, mental or physical hyperactivity, worsened depression, and panic attacks. Your doctor may need to adjust your dose or recommend withdrawing from the treatment temporarily and wait for these side effects to go away. It's also very important that you discuss with your health care provider any health conditions you have and drugs you are taking, as your dose may depend on those. Such health conditions as bipolar disorder, a history of drug abuse, seizures or epilepsy, liver or kidney disease, and a history of suicidal thoughts are supposed to be reported as sometimes that may affect the success of your treatment if you are not monitored carefully for side effects by your doctor. Avoid combining Zoloft with such drugs as digitoxin, lithium, phenytoin, blood thinners, heart rhythm medications, other antidepressants, or tramadol, because of possible interactions, and be aware of the fact such medicines as sleeping pills, muscle relaxers, and narcotic pain medicines can add to the drowsiness you may experience as a result of using Zoloft.